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Dual Functions of DNA Replication Forks in Checkpoint Signaling and PCNA Ubiquitination
During cell proliferation, DNA damage inflicted by intrinsic or extrinsic genotoxic stresses impose a thereat to DNA replication. The stability of the DNA replication forks that encounter DNA damage is crucial for genomic integrity. Both the ATR-regulated checkpoint pathway and the translesion DNA s...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2760427/ https://ncbi.nlm.nih.gov/pubmed/19158510 |
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