Exposure-effect population model of inolimomab, a monoclonal antibody administered in first-line treatment for acute graft-versus-host disease

BACKGROUND: Inolimomab, a monoclonal antibody against IL-2Rα (CD25) has shown promising results in the treatment of steroid-resistant acute graft-versus-host disease (aGvHD). OBJECTIVE: Our purpose was to characterize its pharmacokinetic (PK) and pharmacodynamic (PD) properties in first line treatme...

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Main Authors: Dartois, Céline, Freyer, Gilles, Michallet, Mauricette, Hénin, Emilie, You, Benoît, Darlavoix, Isabelle, Vermot-Desroches, Claudine, Tranchand, Brigitte, Girard, Pascal
Format: Artigo
Jezik:Inglês
Izdano: Adis Intrnational Ltd 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760126/
https://ncbi.nlm.nih.gov/pubmed/17465640
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