Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions

BACKGROUND: Cysteine cathepsins are known to primarily cleave their substrates at reducing and acidic conditions within endo-lysosomes. Nevertheless, they have also been linked to extracellular proteolysis, that is, in oxidizing and neutral environments. Although the impact of reducing or oxidizing...

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Bibliografiska uppgifter
Huvudupphovsmän: Jordans, Silvia, Jenko-Kokalj, Saša, Kühl, Nicole M, Tedelind, Sofia, Sendt, Wolfgang, Brömme, Dieter, Turk, Dušan, Brix, Klaudia
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2009
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759951/
https://ncbi.nlm.nih.gov/pubmed/19772638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-10-23
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