Metals in Anticancer Therapy: Copper(II) Complexes as Inhibitors of the 20S Proteasome

Selective 20S proteasomal inhibition and apoptosis induction were observed when several lines of cancer cells were treated with a series of copper complexes described as [Cu(L(I))Cl] (1), [Cu(L(I))OAc] (2), and [Cu(HL(I))(L(I))]OAc (3), where HL(I) is the ligand 2,4-diiodo-6-((pyridine-2-ylmethylami...

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Autori principali: Hindo, Sarmad Sahiel, Frezza, Michael, Tomco, Dajena, Heeg, Mary Jane, Hryhorczuk, Lew, McGarvey, Bruce R., Dou, Q. Ping, Verani, Cláudio N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759842/
https://ncbi.nlm.nih.gov/pubmed/19559507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2009.05.019
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