Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide

During screening of genes upregulated by lipopolysaccharide (LPS; endotoxin) treatment of bone marrow-derived mouse macrophages, it was unexpectedly found that cholesterol 25-hydroxylase (Ch25h) was strongly upregulated. Treatment of macrophages with 10 ng/ml of LPS for 2 h resulted in a 35-fold inc...

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Main Authors: Diczfalusy, Ulf, Olofsson, Katarina E., Carlsson, Ann-Margreth, Gong, Mei, Golenbock, Douglas T., Rooyackers, Olav, Fläring, Urban, Björkbacka, Harry
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759831/
https://ncbi.nlm.nih.gov/pubmed/19502589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M900107-JLR200
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