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Bz-423 Superoxide Signals B Cell Apoptosis via Mcl-1, Bak, and Bax
Bz-423 is a pro-apoptotic 1,4-benzodiazepine with therapeutic properties in murine models of lupus demonstrating selectivity for autoreactive lymphocytes. Bz-423 modulates the F(1)F(0)-ATPase, inducing the formation of superoxide within the mitochondrial respiratory chain, which then functions as a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2759512/ https://ncbi.nlm.nih.gov/pubmed/19481066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.05.025 |
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