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Unnatural substrates reveal the importance of 8-oxoguanine for in vivo mismatch repair by MutY
Escherchia coli MutY plays an important role in preventing mutations associated with the oxidative lesion 7,8-dihydro-8-oxo-2′-deoxyguanosine (OG) in DNA by excising adenines from OG:A mismatches as the first step of base excision repair. To determine the importance of specific steps in the base pai...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2759348/ https://ncbi.nlm.nih.gov/pubmed/18026095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2007.40 |
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