Towards Preparation of Antibody-based Imaging Probe Libraries for Dual-modality Positron Emission Tomography and Fluorescence Imaging

Two novel imaging agents trastuzumab-Cy5.5-CHX-A″ 1 and cetuximab-Cy7-CHX-A″ 2, bearing both a chelating moiety (CHX-A″) for sequestering metallic radionuclides ((86)Y or (111)In) and the near infrared dye Cy5.5/Cy7, were prepared by a novel modular synthetic strategy as examples of dual-labeled, an...

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Main Authors: Xu, Heng, Eck, Peter K., Baidoo, Kwamena E., Choyke, Peter L., Brechbiel, Martin W.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759299/
https://ncbi.nlm.nih.gov/pubmed/19505829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.05.048
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