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B and CD4+ T cell expression of TLR2 are critical for optimal induction of a T cell-dependent humoral immune response to intact Streptococcus pneumoniae

TLR2−/− mice immunized with Streptococcus pneumoniae (Pn) elicit normal IgM, but defective CD4+ T cell-dependent (TD) type 1 IgG isotype production, associated with a largely intact innate immune response. We studied the TD phosphorylcholine (PC)-specific IgG3 versus the T cell-independent IgM respo...

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Autors principals: Vasilevsky, S., Chattopadhyay, G., Colino, Jesus, Yeh, T-J, Chen, Q., Sen, G., Snapper, C. M.
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759084/
https://ncbi.nlm.nih.gov/pubmed/19003933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200838484
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