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B and CD4+ T cell expression of TLR2 are critical for optimal induction of a T cell-dependent humoral immune response to intact Streptococcus pneumoniae
TLR2−/− mice immunized with Streptococcus pneumoniae (Pn) elicit normal IgM, but defective CD4+ T cell-dependent (TD) type 1 IgG isotype production, associated with a largely intact innate immune response. We studied the TD phosphorylcholine (PC)-specific IgG3 versus the T cell-independent IgM respo...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2759084/ https://ncbi.nlm.nih.gov/pubmed/19003933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200838484 |
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