Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines

Folate deficiency may affect gene expression by disrupting DNA methylation patterns or by inducing base substitution, DNA breaks, gene deletions and gene amplification. Changes in expression may explain the inverse relationship observed between folate status and risk of colorectal cancer. Three cell...

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Bibliographische Detailangaben
Hauptverfasser: Crott, Jimmy W., Liu, Zhenhua, Keyes, Mary K., Choi, Sang-Woon, Jang, Hyeran, Moyer, Mary P., Mason, Joel B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759072/
https://ncbi.nlm.nih.gov/pubmed/17681772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jnutbio.2007.05.003
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