Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro.
Treatment with the phosphatidylinositol 3-kinase inhibitor wortmannin promotes approximately 30% decrease in the steady-state number of cell-surface transferrin receptors. This effect is rapid and dose dependent, with maximal down-regulation elicited with 30 min of treatment and with an IC50 approxi...
Guardat en:
| Publicat a: | Mol Biol Cell |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Cell Biology
1996
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC275889/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8868465/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.7.3.355 |
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