Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro.

Treatment with the phosphatidylinositol 3-kinase inhibitor wortmannin promotes approximately 30% decrease in the steady-state number of cell-surface transferrin receptors. This effect is rapid and dose dependent, with maximal down-regulation elicited with 30 min of treatment and with an IC50 approxi...

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Bibliographic Details
Main Authors: Spiro, D J, Boll, W, Kirchhausen, T, Wessling-Resnick, M
Format: Artigo
Language:Inglês
Published: 1996
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC275889/
https://ncbi.nlm.nih.gov/pubmed/8868465
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