Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro.
Treatment with the phosphatidylinositol 3-kinase inhibitor wortmannin promotes approximately 30% decrease in the steady-state number of cell-surface transferrin receptors. This effect is rapid and dose dependent, with maximal down-regulation elicited with 30 min of treatment and with an IC50 approxi...
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| Publié dans: | Mol Biol Cell |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Cell Biology
1996
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC275889/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8868465/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.7.3.355 |
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