Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro.

Treatment with the phosphatidylinositol 3-kinase inhibitor wortmannin promotes approximately 30% decrease in the steady-state number of cell-surface transferrin receptors. This effect is rapid and dose dependent, with maximal down-regulation elicited with 30 min of treatment and with an IC50 approxi...

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Publicado en:	Mol Biol Cell
Autores principales:	Spiro, D J, Boll, W, Kirchhausen, T, Wessling-Resnick, M
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Cell Biology 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC275889/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8868465/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.7.3.355
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