Comparison of Radiosensitizing Effects of the mTOR Inhibitor CCI-779 to Cisplatin in Experimental Models of Head and Neck Squamous Cell Carcinoma

PURPOSE: To determine if the mTOR inhibitor CCI-779 can sensitize head and neck squamous cell carcinoma (HNSCC) to radiotherapy (XRT) and compare the radiosensitizing effects to cisplatin with its known considerable toxicity. EXPERIMENTAL DESIGN: Radiosensitizing effects of CCI-779 were assayed on H...

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Detalhes bibliográficos
Main Authors: Ekshyyan, Oleksandr, Rong, Youhua, Rong, Xiaohua, Pattani, Kavita M., Abreo, Fleurette, Caldito, Gloria, Chang, John Kai Siung, Ampil, Federico, Glass, Jonathan, Nathan, Cherie-Ann O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758817/
https://ncbi.nlm.nih.gov/pubmed/19625495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-1184
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