Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

The DNA binding activity of p53 is crucial for its tumor suppressor function and is subject to tight regulation. Previous studies revealed that the inhibitory function of the p53 C terminus is implicated in the latent, low affinity sequence-specific DNA binding activity of p53 in the uninduced state...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Müller-Tiemann, Beate F., Halazonetis, Thanos D., Elting, James J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1998
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27588/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9600920/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.11.6079
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