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Targeting Jak2 in Her2/neu-expressing mammary cancer: implications for cancer prevention and therapy
Jak2 is essential for normal mammary gland development, but this tyrosine kinase and its main effector Stat5 are also active in a significant subset of human breast cancers. We have recently reported that Jak2 controls the expression and nuclear accumulation of Cyclin D1. Since this particular D-typ...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2758773/ https://ncbi.nlm.nih.gov/pubmed/19638583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0746 |
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