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ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer’s but not normal brain
The ε4 allele of ApoE is associated with an earlier onset and faster progression of Alzheimer’s disease in patients with the familial form of this neurodegenerative condition. Although ApoE4 has been repeatedly associated with altered sphingomyelin and cholesterol levels in tissue culture and rodent...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2758772/ https://ncbi.nlm.nih.gov/pubmed/17888544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2007.07.024 |
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