Function of Mitochondrial Stat3 in Cellular Respiration

Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in the mitochondria of cultured cells and primary tissues, including the liver and heart. In Stat3(−/−) cells, the activ...

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Bibliografiske detaljer
Main Authors: Wegrzyn, Joanna, Potla, Ramesh, Chwae, Yong-Joon, Sepuri, Naresh B. V., Zhang, Qifang, Koeck, Thomas, Derecka, Marta, Szczepanek, Karol, Szelag, Magdalena, Gornicka, Agnieszka, Moh, Akira, Moghaddas, Shadi, Chen, Qun, Bobbili, Santha, Cichy, Joanna, Dulak, Jozef, Baker, Darren P., Wolfman, Alan, Stuehr, Dennis, Hassan, Medhat O., Fu, Xin-Yuan, Avadhani, Narayan, Drake, Jennifer I., Fawcett, Paul, Lesnefsky, Edward J., Larner, Andrew C.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758306/
https://ncbi.nlm.nih.gov/pubmed/19131594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1164551
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