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Histone Deacetylase Inhibitor Romidepsin Enhances Anti-Tumor Effect of Erlotinib in Non-small Cell Lung Cancer (NSCLC) Cell Lines

INTRODUCTION: Most epidermal growth factor receptor (EGFR) mutant non-small cell lung cancers (NSCLCs) are sensitive to EGFR tyrosine kinase inhibitors (TKIs) such as erlotinib or gefitinib, but many EGFR wild type NSCLCs are resistant to TKIs. In this study, we examined the effects of the histone d...

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Detalhes bibliográficos
Main Authors: Zhang, Wei, Peyton, Michael, Xie, Yang, Soh, Junichi, Minna, John D., Gazdar, Adi F., Frenkel, Eugene P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758160/
https://ncbi.nlm.nih.gov/pubmed/19179890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e318194fae7
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