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Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

Reprogramming differentiated human cells to induced pluripotent stem (iPS) cells has applications in basic biology, drug development, and transplantation. Human iPS cell derivation previously required vectors that integrate into the genome, which can create mutations and limit the utility of the cel...

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Detalhes bibliográficos
Main Authors: Yu, Junying, Hu, Kejin, Smuga-Otto, Kim, Tian, Shulan, Stewart, Ron, Slukvin, Igor I., Thomson, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758053/
https://ncbi.nlm.nih.gov/pubmed/19325077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1172482
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