Syndecan-1 Is Required for Robust Growth, Vascularization, and Metastasis of Myeloma Tumors in Vivo

Myeloma tumors are characterized by high expression of syndecan-1 (CD138), a heparan sulfate proteoglycan present on the myeloma cell surface and shed into the tumor microenvironment. High levels of shed syndecan-1 in the serum of patients are an indicator of poor prognosis, and numerous studies hav...

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Bibliographic Details
Main Authors: Khotskaya, Yekaterina B., Dai, Yuemeng, Ritchie, Joseph P., MacLeod, Veronica, Yang, Yang, Zinn, Kurt, Sanderson, Ralph D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758008/
https://ncbi.nlm.nih.gov/pubmed/19596856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.018473
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