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PARP-1 Deficiency Increases the Severity of Disease in a Mouse Model of Multiple Sclerosis

Poly(ADP-ribose) polymerase-1 (PARP-1) has been implicated in the pathogenesis of several central nervous system (CNS) disorders. However, the role of PARP-1 in autoimmune CNS injury remains poorly understood. Therefore, we studied experimental autoimmune encephalomyelitis (EAE), a model for multipl...

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Hlavní autoři: Selvaraj, Vimal, Soundarapandian, Mangala M., Chechneva, Olga, Williams, Ambrose J., Sidorov, Maxim K., Soulika, Athena M., Pleasure, David E., Deng, Wenbin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758007/
https://ncbi.nlm.nih.gov/pubmed/19628872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.013474
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