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The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis

The mitochondrial translocator protein (TSPO) has been implicated in CNS diseases. Here, we sought to determine the specific role of TSPO in experimental autoimmune encephalomyelitis (EAE), the most studied animal model of multiple sclerosis (MS). To fundamentally elucidate the functions of TSPO, we...

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Publicado en:Sci Rep
Autores principales: Daugherty, Daniel J., Chechneva, Olga, Mayrhofer, Florian, Deng, Wenbin
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772008/
https://ncbi.nlm.nih.gov/pubmed/26925573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22556
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