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The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis

The mitochondrial translocator protein (TSPO) has been implicated in CNS diseases. Here, we sought to determine the specific role of TSPO in experimental autoimmune encephalomyelitis (EAE), the most studied animal model of multiple sclerosis (MS). To fundamentally elucidate the functions of TSPO, we...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Daugherty, Daniel J., Chechneva, Olga, Mayrhofer, Florian, Deng, Wenbin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772008/
https://ncbi.nlm.nih.gov/pubmed/26925573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22556
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