Statin's Excitoprotection Is Mediated by sAPP and the Subsequent Attenuation of Calpain-Induced Truncation Events, Likely via Rho-ROCK Signaling

The widely used cholesterol-lowering drugs, statins, were reported to reduce the incidence of stroke and the progression of Alzheimer's disease. However, little is known on how statins exert these beneficial effects. In this study, we investigated the molecular mechanisms underlying the neuropr...

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Detalhes bibliográficos
Main Authors: Ma, Tao, Zhao, YongBo, Kwak, Young-Don, Yang, Zhangmin, Thompson, Robert, Luo, Zhijun, Xu, Huaxi, Liao, Francesca-Fang
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757921/
https://ncbi.nlm.nih.gov/pubmed/19741129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6150-08.2009
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