Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?

The INSIG2 rs7566605 polymorphism was identified for obesity (BMI≥30 kg/m(2)) in one of the first genome-wide association studies, but replications were inconsistent. We collected statistics from 34 studies (n = 74,345), including general population (GP) studies, population-based studies with subjec...

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Main Authors: Heid, Iris M., Huth, Cornelia, Loos, Ruth J. F., Kronenberg, Florian, Adamkova, Vera, Anand, Sonia S., Ardlie, Kristin, Biebermann, Heike, Bjerregaard, Peter, Boeing, Heiner, Bouchard, Claude, Ciullo, Marina, Cooper, Jackie A., Corella, Dolores, Dina, Christian, Engert, James C., Fisher, Eva, Francès, Francesc, Froguel, Philippe, Hebebrand, Johannes, Hegele, Robert A., Hinney, Anke, Hoehe, Margret R., Hu, Frank B., Hubacek, Jaroslav A., Humphries, Steve E., Hunt, Steven C., Illig, Thomas, Järvelin, Marjo-Riita, Kaakinen, Marika, Kollerits, Barbara, Krude, Heiko, Kumar, Jitender, Lange, Leslie A., Langer, Birgit, Li, Shengxu, Luchner, Andreas, Lyon, Helen N., Meyre, David, Mohlke, Karen L., Mooser, Vincent, Nebel, Almut, Nguyen, Thuy Trang, Paulweber, Bernhard, Perusse, Louis, Qi, Lu, Rankinen, Tuomo, Rosskopf, Dieter, Schreiber, Stefan, Sengupta, Shantanu, Sorice, Rossella, Suk, Anita, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Völzke, Henry, Vimaleswaran, Karani S., Wareham, Nicholas J., Waterworth, Dawn, Yusuf, Salim, Lindgren, Cecilia, McCarthy, Mark I., Lange, Christoph, Hirschhorn, Joel N., Laird, Nan, Wichmann, H.-Erich
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757909/
https://ncbi.nlm.nih.gov/pubmed/19851442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000694
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