Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons

Fragile X syndrome is caused by lack of the protein FMRP. FMRP mediates mRNA binding, dendritic mRNA transport and translational control at spines. We examined the role of functional domains of FMRP in neuronal RNA-granule formation and dendritic transport using different FMRP variants, including th...

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Bibliographic Details
Main Authors: Levenga, Josien, Buijsen, Ronald A.M., Rifé, Maria, Moine, Herve, Nelson, David L., Oostra, Ben A., Willemsen, Rob, de Vrij, Femke M.S.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757577/
https://ncbi.nlm.nih.gov/pubmed/19464371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2009.05.004
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