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Overexpression of Type I Adenylyl Cyclase in the Forebrain Impairs Spatial Memory in Aged But Not Young Mice

Hippocampus-dependent memory requires a cAMP signal that is generated by Ca(2+)-stimulated adenylyl cyclases (AC1, AC8). Young transgenic mice overexpressing AC1 in the forebrain (AC1(+) mice) have enhanced hippocampal long-term potentiation, superior memory for novel object recognition and more per...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Garelick, Michael G., Chan, Guy C. K., DiRocco, Derek P., Storm, Daniel R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society for Neuroscience 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757415/
https://ncbi.nlm.nih.gov/pubmed/19726641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0553-09.2009
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