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Overexpression of Type I Adenylyl Cyclase in the Forebrain Impairs Spatial Memory in Aged But Not Young Mice
Hippocampus-dependent memory requires a cAMP signal that is generated by Ca(2+)-stimulated adenylyl cyclases (AC1, AC8). Young transgenic mice overexpressing AC1 in the forebrain (AC1(+) mice) have enhanced hippocampal long-term potentiation, superior memory for novel object recognition and more per...
Gorde:
| Egile Nagusiak: | , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Society for Neuroscience
2009
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757415/ https://ncbi.nlm.nih.gov/pubmed/19726641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0553-09.2009 |
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