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Overexpression of Type I Adenylyl Cyclase in the Forebrain Impairs Spatial Memory in Aged But Not Young Mice
Hippocampus-dependent memory requires a cAMP signal that is generated by Ca(2+)-stimulated adenylyl cyclases (AC1, AC8). Young transgenic mice overexpressing AC1 in the forebrain (AC1(+) mice) have enhanced hippocampal long-term potentiation, superior memory for novel object recognition and more per...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757415/ https://ncbi.nlm.nih.gov/pubmed/19726641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0553-09.2009 |
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