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Inhibition and Activation by CD244 Depends on CD2 and Phospholipase C-γ1
Regulation by the NK and T cell surface receptor CD244 in mice and humans depends both on engagement at the cell surface by CD48 and intracellular interactions with SAP and EAT-2. Relevance to human disease by manipulating CD244 in mouse models is complicated by rodent CD2 also binding CD48. We dist...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757176/ https://ncbi.nlm.nih.gov/pubmed/19586919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.028209 |
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