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ENDOR Spectroscopy Shows Guanine N1 Binds to [4Fe-4S] Cluster II of the S-adenosyl methionine-dependent enzyme MoaA - Mechanistic Implications

[Image: see text] The SAM-dependent enzyme MoaA, in concert with MoaC, catalyzes the first step of molybdenum cofactor biosynthesis, the conversion of 5′-GTP into precursor Z. A published X-ray crystal structure of MoaA with the substrate 5′-GTP revealed that the substrate might be binding to the un...

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Detalhes bibliográficos
Main Authors: Lees, Nicholas S., Hänzelmann, Petra, Hernandez, Heather L., Subramanian, Sowmya, Schindelin, Hermann, Johnson, Michael K., Hoffman, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757093/
https://ncbi.nlm.nih.gov/pubmed/19566093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja903978u
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