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Caffeine inhibition of ionotropic glycine receptors
We found that caffeine is a structural analogue of strychnine and a competitive antagonist at ionotropic glycine receptors (GlyRs). Docking simulations indicate that caffeine and strychnine may bind to similar sites at the GlyR. The R131A GlyR mutation, which reduces strychnine antagonism without su...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756438/ https://ncbi.nlm.nih.gov/pubmed/19564396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.174797 |
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