Nitrosative-stress induced S-glutathionylation of PDI leads to activation of the unfolded protein response

The rapid proliferation of cancer cells mandates a high protein turnover. The endoplasmic reticulum (ER) is intimately involved in protein processing. An accumulation of unfolded or misfolded proteins in the ER leads to a cascade of transcriptional and translational events collectively referred to a...

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Main Authors: Townsend, Danyelle M., Manevich, Yefim, He, Lin, Xiong, Ying, Bowers, Robert R., Hutchens, Steven, Tew, Kenneth D.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756322/
https://ncbi.nlm.nih.gov/pubmed/19773442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0493
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