MYC activity mitigates response to rapamycin in prostate cancer through 4EBP1-mediated inhibition of autophagy

Loss of PTEN and activation of PI3K are commonly observed in advanced prostate cancer. Inhibition of mTOR, a downstream target of PI3K signaling, results in cell cycle arrest and apoptosis in multiple in vitro and in vivo models of prostate cancer. However, single agent use of mTOR inhibition has li...

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Detalhes bibliográficos
Principais autores: Balakumaran, Bala S., Porrello, Alessandro, Hsu, David S., Glover, Wayne, Foye, Adam, Leung, Janet Y., Sullivan, Beth A., Hahn, William C., Loda, Massimo, Febbo, Phillip G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756305/
https://ncbi.nlm.nih.gov/pubmed/19773438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0910
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