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Antineoplastic Agents 552. Oxidation of Combretastatin A-1: Trapping the o-Quinone Intermediate Considered the Metabolic Product of the Corresponding Phosphate Prodrug 1
The very unstable (< 10 min at rt) o-quinone (5) derived from the vicinal diphenol anticancer drug combretastatin A-1 (1) has been obtained by careful oxidation with NaIO(4) and tetrabutylammonium bromide in water/dichloromethane. Immediate reaction with phenylenediamine (6) allowed o-quinone 5 t...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756244/ https://ncbi.nlm.nih.gov/pubmed/18729517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np800179g |
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