K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses.

The same receptor tyrosine kinase (RTK) can mediate strikingly different biological responses in a fibroblast as opposed to a neuron. We have compared the rapidly induced tyrosine phosphorylations mediated by various RTKs in both NIH3T3 fibroblasts and in the PC12 neuronal precursor cell line and fo...

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Pubblicato in:	Mol Biol Cell
Autori principali:	Nye, S H, Squinto, S P, Glass, D J, Stitt, T N, Hantzopoulos, P, Macchi, M J, Lindsay, N S, Ip, N Y, Yancopoulos, G D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Cell Biology 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC275622/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1323351/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.3.6.677
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