K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses.

The same receptor tyrosine kinase (RTK) can mediate strikingly different biological responses in a fibroblast as opposed to a neuron. We have compared the rapidly induced tyrosine phosphorylations mediated by various RTKs in both NIH3T3 fibroblasts and in the PC12 neuronal precursor cell line and fo...

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Detalhes bibliográficos
Main Authors: Nye, S H, Squinto, S P, Glass, D J, Stitt, T N, Hantzopoulos, P, Macchi, M J, Lindsay, N S, Ip, N Y, Yancopoulos, G D
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC275622/
https://ncbi.nlm.nih.gov/pubmed/1323351
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