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Evolution of the Antibiotic Resistance Protein, FosA, is Linked to a Catalytically Promiscuous Progenitor
The fosfomycin (1) resistance proteins FosA and FosX in pathogenic microorganisms are related to a catalytically promiscuous progenitor encoded in a phn operon in Mesorhizobium loti. The mlr3345 gene product (FosX(Ml)) from M. loti has a very low epoxide hydrolase activity and even lower glutathione...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756217/ https://ncbi.nlm.nih.gov/pubmed/19196010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900078q |
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