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Fucosylated chondroitin sulfate inhibits plasma thrombin generation via targeting of the factor IXa heparin-binding exosite

Depolymerized holothurian glycosaminoglycan (DHG) is a fucosylated chondroitin sulfate with antithrombin-independent antithrombotic properties. Heparin cofactor II (HCII)-dependent and -independent mechanisms for DHG inhibition of plasma thrombin generation were evaluated. When thrombin generation w...

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Detalhes bibliográficos
Main Authors: Buyue, Yang, Sheehan, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756211/
https://ncbi.nlm.nih.gov/pubmed/19414859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-203661
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