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MUTATION OF THE ACTIVE SITE CARBOXY-LYSINE (K70) OF OXA-1 β-LACTAMASE RESULTS IN A DEACYLATION-DEFICIENT ENZYME

Class D β-lactamases hydrolyze β-lactam antibiotics by using an active site serine nucleophile to form a covalent acyl-enzyme intermediate, and subsequently employ water to deacylate the β-lactam and release product. Class D β-lactamases are carboxylated on the ε-amino group of an active site lysine...

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書目詳細資料
Main Authors: Schneider, Kyle D., Bethel, Christopher R., Distler, Anne M., Hujer, Andrea M., Bonomo, Robert A., Leonard, David A.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756174/
https://ncbi.nlm.nih.gov/pubmed/19485421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900448u
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