Distinct spatio-temporal Ca(2+) signaling elicited by integrin α2β1 and glycoprotein VI under flow

We studied how integrin α2β1 and glycoprotein VI (GPVI) contribute to collagen-induced platelet activation under flow conditions by evaluating stable adhesion and intracellular Ca(2+) concentration ([Ca(2+)](i)) of FLUO 3-AM–labeled platelets perfused over acid-soluble type I or microfibrillar type...

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Autores principales: Mazzucato, Mario, Cozzi, Maria Rita, Battiston, Monica, Jandrot-Perrus, Martine, Mongiat, Maurizio, Marchese, Patrizia, Kunicki, Thomas J., Ruggeri, Zaverio M., De Marco, Luigi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2009
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756134/
https://ncbi.nlm.nih.gov/pubmed/19622836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-193490
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