Preclinical characterization of 1-7F9, a novel human anti–KIR receptor therapeutic antibody that augments natural killer–mediated killing of tumor cells

Inhibitory-cell killer immunoglobulin-like receptors (KIR) negatively regulate natural killer (NK) cell–mediated killing of HLA class I–expressing tumors. Lack of KIR-HLA class I interactions has been associated with potent NK-mediated antitumor efficacy and increased survival in acute myeloid leuke...

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Detalhes bibliográficos
Main Authors: Romagné, Francois, André, Pascale, Spee, Pieter, Zahn, Stefan, Anfossi, Nicolas, Gauthier, Laurent, Capanni, Marusca, Ruggeri, Loredana, Benson, Don M., Blaser, Bradley W., Della Chiesa, Mariella, Moretta, Alessandro, Vivier, Eric, Caligiuri, Michael A., Velardi, Andrea, Wagtmann, Nicolai
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756126/
https://ncbi.nlm.nih.gov/pubmed/19553639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-206532
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