Identification of a Disulfide Bridge Essential for Transport Function of the Human Proton-coupled Amino Acid Transporter hPAT1

The proton-coupled amino acid transporter 1 (PAT1, SLC36A1) mediates the uptake of small neutral amino acids at the apical membrane of intestinal epithelial cells after protein digestion. The transporter is currently under intense investigation, because it is a possible vehicle for oral drug deliver...

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Hlavní autoři: Dorn, Madlen, Weiwad, Matthias, Markwardt, Fritz, Laug, Linda, Rudolph, Rainer, Brandsch, Matthias, Bosse-Doenecke, Eva
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Membrane Transport, Structure, Function, and Biogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755936/
https://ncbi.nlm.nih.gov/pubmed/19549785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.023713
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