Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H(+)-coupled amino-acid transporter hPAT1

1. The aim of this investigation was to determine if the human proton-coupled amino-acid transporter 1 (hPAT1 or SLC36A1) is responsible for the intestinal uptake of the orally-administered antiepileptic agent 4-amino-5-hexanoic acid (vigabatrin). 2. The Caco-2 cell line was used as a model of the h...

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Bibliographic Details
Main Authors: Abbot, Emily L, Grenade, Danielle S, Kennedy, David J, Gatfield, Kelly M, Thwaites, David T
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2005
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751303/
https://ncbi.nlm.nih.gov/pubmed/16331283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706557
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