TDP-43 Depletion Induces Neuronal Cell Damage through Dysregulation of Rho Family GTPases

The 43-kDa TAR DNA-binding protein (TDP-43) is known to be a major component of the ubiquitinated inclusions characteristic of amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin-positive inclusions. Although TDP-43 is a nuclear protein, it disappears from the nucleus...

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Main Authors: Iguchi, Yohei, Katsuno, Masahisa, Niwa, Jun-ichi, Yamada, Shin-ichi, Sone, Jun, Waza, Masahiro, Adachi, Hiroaki, Tanaka, Fumiaki, Nagata, Koh-ichi, Arimura, Nariko, Watanabe, Takashi, Kaibuchi, Kozo, Sobue, Gen
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Molecular Basis of Cell and Developmental Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755930/
https://ncbi.nlm.nih.gov/pubmed/19535326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.012195
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