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Juxtamembranous Region of the Amino Terminus of the Family B G Protein-coupled Calcitonin Receptor Plays a Critical Role in Small-molecule Agonist Action

The Family B G protein-coupled calcitonin receptor is an important drug target. The aim of this work was to elucidate the molecular mechanism of action of small-molecule agonist ligands acting at this receptor, comparing it with the action mechanism of the receptor's natural peptide ligand. cAM...

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Détails bibliographiques
Auteurs principaux: Dong, Maoqing, Cox, Richard F., Miller, Laurence J.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755908/
https://ncbi.nlm.nih.gov/pubmed/19447889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011924
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