Unidirectional Cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71

The Cre/loxP recombination system is a commonly used tool to alter the mouse genome in a conditional manner by deletion or inversion of loxP-flanked DNA segments. While Cre-mediated deletion is essentially unidirectional, inversion is reversible and therefore does not allow the stable alteration of...

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Опубликовано в::	Nucleic Acids Res
Главные авторы:	Oberdoerffer, Philipp, Otipoby, Kevin L., Maruyama, Mitsuo, Rajewsky, Klaus
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Oxford University Press 2003
Предметы:	NAR Methods Online
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC275577/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14602933/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gng140
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