A Portable Hot Spot Recognition Loop Transfers Sequence Preferences from APOBEC Family Members to Activation-induced Cytidine Deaminase

Enzymes of the AID/APOBEC family, characterized by the targeted deamination of cytosine to generate uracil within DNA, mediate numerous critical immune responses. One family member, activation-induced cytidine deaminase (AID), selectively introduces uracil into antibody variable and switch regions,...

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Autors principals: Kohli, Rahul M., Abrams, Shaun R., Gajula, Kiran S., Maul, Robert W., Gearhart, Patricia J., Stivers, James T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755697/
https://ncbi.nlm.nih.gov/pubmed/19561087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025536
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