B Cell Receptor-induced Phosphorylation of Pyk2 and Focal Adhesion Kinase Involves Integrins and the Rap GTPases and Is Required for B Cell Spreading

Signaling by the B cell receptor (BCR) promotes integrin-mediated adhesion and cytoskeletal reorganization. This results in B cell spreading, which enhances the ability of B cells to bind antigens and become activated. Proline-rich tyrosine kinase (Pyk2) and focal adhesion kinase (FAK) are related c...

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Detalhes bibliográficos
Main Authors: Tse, Kathy W. K., Dang-Lawson, May, Lee, Rosaline L., Vong, Doris, Bulic, Anica, Buckbinder, Leonard, Gold, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755694/
https://ncbi.nlm.nih.gov/pubmed/19561089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.013169
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