Importin-β Is a GDP-to-GTP Exchange Factor of Ran: IMPLICATIONS FOR THE MECHANISM OF NUCLEAR IMPORT

Ran-GTP interacts strongly with importin-β, and this interaction promotes the release of the importin-α-nuclear localization signal cargo from importin-β. Ran-GDP also interacts with importin-β, but this interaction is 4 orders of magnitude weaker than the Ran-GTP·importin-β interaction. Here we use...

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Bibliographic Details
Main Authors: Lonhienne, Thierry G., Forwood, Jade K., Marfori, Mary, Robin, Gautier, Kobe, Bostjan, Carroll, Bernard J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Membrane Transport, Structure, Function, and Biogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755662/
https://ncbi.nlm.nih.gov/pubmed/19549784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.019935
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