FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt

Akt is a central regulator of cell growth. Its activity can be negatively regulated by the phosphatase PHLPP that specifically dephosphorylates the hydrophobic motif of Akt (Ser473 in Akt1). However, how PHLPP is targeted to Akt is not clear. Here we show that FKBP51 (FK506-binding protein 51) acts...

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Main Authors: Pei, Huadong, Li, Liang, Fridley, Brooke L., Jenkins, Gregory D., Kalari, Krishna R., Lingle, Wilma, Petersen, Gloria, Lou, Zhenkun, Wang, Liewei
格式: Artigo
語言:Inglês
出版: 2009
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755578/
https://ncbi.nlm.nih.gov/pubmed/19732725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.07.016
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