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Reciprocal Efficiency of RNQ1 and Polyglutamine Detoxification in the Cytosol and Nucleus

Onset of proteotoxicity is linked to change in the subcellular location of proteins that cause misfolding diseases. Yet, factors that drive changes in disease protein localization and the impact of residence in new surroundings on proteotoxicity are not entirely clear. To address these issues, we ex...

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Autors principals: Douglas, Peter M., Summers, Daniel W., Ren, Hong-Yu, Cyr, Douglas M.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754930/
https://ncbi.nlm.nih.gov/pubmed/19656852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-02-0170
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